发给老马备查:8 P# c1 h3 _, _& Z2 M2 x2 a* I
滴水察海(69304838) 15:23:23
i8 h( K% {" N9 A5 `老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱) f2 B' t' ?5 E
吉非替尼和S-1连用的依据9 r8 {0 y$ B8 [) y; q
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
7 u1 i2 [6 k$ h# C, i+ j0 A是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达6 o2 P: T+ ?) ?) [( D+ |
这样是不是推理出,耐药后,可以用S-1和培美了?1 \% _' @ ?& f
结论:
. N! E( J# K# h( T1 f$ f: ~' ~如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |