发给老马备查:
; C! |7 b; u1 J, ?: H滴水察海(69304838) 15:23:23
" l' U3 J" t5 ]: e% F老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱; O' q+ P U9 L0 y) t& A3 E
吉非替尼和S-1连用的依据4 ?8 U$ G; f9 t
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.2 |' k. J4 U; ^/ c6 n
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
: l" T J( }; K; y0 `; v+ [这样是不是推理出,耐药后,可以用S-1和培美了?
- Q+ A2 M/ ]7 \! O结论:8 p! i, w! B% S' h
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |