发给老马备查:
* C8 e K, f3 }- `" R+ M0 t滴水察海(69304838) 15:23:23
: q6 E- Z2 Y4 {$ }% D老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱( W' C7 h% y8 H- m# c
吉非替尼和S-1连用的依据
: B! d& z: }) w# W$ `Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.' _2 i7 v7 u/ w3 O; Y
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
& t4 r8 ]& E2 R. G- }- v0 ]这样是不是推理出,耐药后,可以用S-1和培美了?1 t! a% E, Q$ r6 l2 K$ m/ ?9 Y
结论:
8 @6 ]$ {5 C% C: a如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |